Adult-onset leukodystrophies and genetic leukoencephalopathies comprise a diverse group of neurodegenerative disorders of white matter with a wide age of onset and phenotypic spectrum. Patients with ...

Dr H Blaszyk, Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation,200 First Street SW, Rochester, Minnesota, 55902, USA. Telephone 001 507 284 2511; fax 001 507 284 1599; email ...

Background: Prompt assessment and investigation of transient ischaemic attack (TIA) followed by early initiation of secondary prevention is effective in reducing recurrent stroke. Nevertheless, many ...

Objective To compare survival, life expectancies (LE), and the anticipated age at the time of death (AAD), in a community-based cohort of Parkinson's disease (PD) patients with and without significant ...

Background Recurrent attacks in neuromyelitis optica spectrum disorders (NMOSDs) or myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) can lead to severe disability. We aimed to ...

Introduction Limited data exist on brain MRI enhancement in myelin-oligodendrocyte-glycoprotein (MOG) antibody-associated disease (MOGAD) and differences from ...

Correspondence to: Professor AJ Lees, Reta Lila Weston Institute of Neurological Studies, Royal Free and University College London Medical School, Windeyer Institute of Medical Science, 46 Cleveland ...

University Hospital Essen, Institute of Pathology and Neuropathology, Essen, Germany Correspondence to Dr D Holle, University Hospital Essen, Department of Neurology, Hufelandstrasse 55, 45122 Essen, ...

Correspondence to Dr Claire J Steves, Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK; claire.j.steves{at}kcl.ac.uk Background Mental health issues have ...

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OBJECTIVE Intractable epilepsy is related to various transient and chronic brain electric and neurochemical disturbances. There is increasing evidence that chronic epilepsy induces secondary neuronal ...

Objectives: We report here the clinical and genetic features of two new families with autosomal dominant progressive external ophthalmoplegia (adPEO). Patients and methods: The examination of index ...