Its flagship academic medical centers in Boston, Massachusetts General Hospital and Brigham and Women’s Hospital, anchor a health care hub that is arguably the best in the country, if not the world. Reimbursement rates from insurers are growing more slowly than expenses.

BOSTON - Mass General Brigham, the largest health care system in Massachusetts, announced layoffs Monday that will affect hundreds of workers, citing a $250 million projected budget gap.

Mass General Brigham attributed the layoffs to an expected budget shortfall of $250 billion over the next two years.

Mass General Brigham announced mass layoffs aimed to bridge a $250 million budget gap projected over the next two years in a letter to employees Monday — meaning potentially hundreds of